Fatty acid ethyl ester synthase inhibition ameliorates ethanol-induced Ca2+-dependent mitochondrial dysfunction and acute pancreatitis

@inproceedings{Huang2014FattyAE,
  title={Fatty acid ethyl ester synthase inhibition ameliorates ethanol-induced Ca2+-dependent mitochondrial dysfunction and acute pancreatitis},
  author={Wei Huang and David M. Booth and Matthew C. Cane and Michael Chvanov and Muhammad Ahsan Javed and Victoria Lynn Elliott and Jane A. Armstrong and Hayley Dingsdale and Nicole Cash and Y. M. Li and William Greenhalf and Rajarshi Mukherjee and Bhupendra S. Kaphalia and M. Jamal Mohamed Jaffar and Ole H Petersen and Alexei V Tepikin and Robert Sutton and David Neil Criddle},
  booktitle={Gut},
  year={2014}
}
OBJECTIVE Non-oxidative metabolism of ethanol (NOME) produces fatty acid ethyl esters (FAEEs) via carboxylester lipase (CEL) and other enzyme action implicated in mitochondrial injury and acute pancreatitis (AP). This study investigated the relative importance of oxidative and non-oxidative pathways in mitochondrial dysfunction, pancreatic damage and development of alcoholic AP, and whether deleterious effects of NOME are preventable. DESIGN Intracellular calcium ([Ca(2+)](C)), NAD(P)H… CONTINUE READING

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