Fatty acid-dependent globotriaosyl ceramide receptor function in detergent resistant model membranes.

Abstract

Glycosphingolipid (GSL) fatty acid strictly regulates verotoxin 1 (VT1) and the HIV adhesin, gp120 binding to globotriaosyl ceramide within Gb(3)/cholesterol detergent resistant membrane (DRM) vesicle constructs and in Gb(3) water-air interface monolayers in a similar manner. VT2 bound Gb(3)/cholesterol vesicles irrespective of fatty acid composition, but… (More)
DOI: 10.1194/jlr.M800385-JLR200

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