Fatty acid chain is a critical epitope for antiphospholipid antibody

@article{Levy1990FattyAC,
  title={Fatty acid chain is a critical epitope for antiphospholipid antibody},
  author={Roger Aaron Levy and Azzudin E. Gharavi and Lisa R. Sammaritano and Ladislav Habina and Michael D. Lockshin},
  journal={Journal of Clinical Immunology},
  year={1990},
  volume={10},
  pages={141-145}
}
To explore the role of phospholipid fatty acids in binding of antiphospholipid antibody (aPL) in ELISA, we tested aPL binding to phospholipids containing fatty acids of varying chain length and degree of saturation using direct ELISA and inhibition methods. Polyclonal IgG and IgM human aPL's bind to C18:1 phosphatidylglycerol (PG) better than to C18:0 PG or… CONTINUE READING