Fatty acid bile acid conjugates (FABACs)--new molecules for the prevention of cholesterol crystallisation in bile.

@article{Gilat2001FattyAB,
  title={Fatty acid bile acid conjugates (FABACs)--new molecules for the prevention of cholesterol crystallisation in bile.},
  author={Tuvia Gilat and G J Somjen and Yehuda Mazur and Alicia I Leikin-Frenkel and Ruth Rosenberg and Zamir Halpern and Fred Meir Konikoff},
  journal={Gut},
  year={2001},
  volume={48 1},
  pages={75-9}
}
BACKGROUND Cholesterol gall stones are a frequent disease for which at present surgery is the usual therapy. Despite the importance of bile acids it has become evident that phospholipids are the main cholesterol solubilisers in bile. Even phospholipid components, such as fatty acids, have anticrystallising activity. AIM To synthesise fatty acid bile acid conjugates (FABACs) and study their effects on cholesterol crystallisation in bile in vitro and in vivo. METHODS FABACs were prepared by… CONTINUE READING
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