Fatty acid and amino acid modulation of glucose cycling in isolated rat hepatocytes.

  title={Fatty acid and amino acid modulation of glucose cycling in isolated rat hepatocytes.},
  author={Lori A Gustafson and Maaike Neeft and Dirk-Jan Reijngoud and Folkert Kuipers and Hans P. Sauerwein and Johannes Anthonius Romijn and Andreas Waldemar Herling and H J Burger and Alfred J. Meijer},
  journal={The Biochemical journal},
  volume={358 Pt 3},
We studied the influence of glucose/glucose 6-phosphate cycling on glycogen deposition from glucose in fasted-rat hepatocytes using S4048 and CP320626, specific inhibitors of glucose-6-phosphate translocase and glycogen phosphorylase respectively. The effect of amino acids and oleate was also examined. The following observations were made: (1) with glucose alone, net glycogen production was low. Inhibition of glucose-6-phosphate translocase increased intracellular glucose 6-phosphate (3-fold… CONTINUE READING


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