Fatty acid amide hydrolase inhibitors: a patent review (2009 – 2014)

@article{Lodola2015FattyAA,
  title={Fatty acid amide hydrolase inhibitors: a patent review (2009 – 2014)},
  author={A. Lodola and Riccardo Castelli and M. Mor and S. Rivara},
  journal={Expert Opinion on Therapeutic Patents},
  year={2015},
  volume={25},
  pages={1247 - 1266}
}
Introduction: Fatty acid amide hydrolase (FAAH) is a key enzyme responsible for the degradation of the endocannabinoid anandamide. FAAH inactivation is emerging as a strategy to treat several CNS and peripheral diseases, including inflammation and pain. The search for effective FAAH inhibitors has thus become a key focus in present drug discovery. Areas covered: Patents and patent applications published from 2009 to 2014 in which novel chemical classes are claimed to inhibit FAAH. Expert… Expand
39 Citations

Paper Mentions

A perspective review on fatty acid amide hydrolase (FAAH) inhibitors as potential therapeutic agents.
  • R. Tripathi
  • Chemistry, Medicine
  • European journal of medicinal chemistry
  • 2019
  • 12
Piperidine and piperazine inhibitors of fatty acid amide hydrolase targeting excitotoxic pathology.
  • 3
Exploring the fatty acid amide hydrolase and cyclooxygenase inhibitory properties of novel amide derivatives of ibuprofen
  • 1
Benzylamides and piperazinoarylamides of ibuprofen as fatty acid amide hydrolase inhibitors
  • 5
  • PDF
Discovery and evaluation of novel FAAH inhibitors in neuropathic pain model.
  • 16
N-aryl 2-aryloxyacetamides as a new class of fatty acid amide hydrolase (FAAH) inhibitors
  • 3
  • PDF
Elevated Brain Fatty Acid Amide Hydrolase Induces Depressive-Like Phenotypes in Rodent Models: A Review
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