Fatty acid amide hydrolase (FAAH) inhibition enhances memory acquisition through activation of PPAR-alpha nuclear receptors.

@article{Mazzola2009FattyAA,
  title={Fatty acid amide hydrolase (FAAH) inhibition enhances memory acquisition through activation of PPAR-alpha nuclear receptors.},
  author={Carmen Mazzola and Julie Medalie and Maria Scherma and Leigh V. Panlilio and Marcello Solinas and Gianluigi Tanda and Filippo Drago and Jean Lud Cadet and Steven R. Goldberg and Sevil Yasar},
  journal={Learning & memory},
  year={2009},
  volume={16 5},
  pages={332-7}
}
Inhibitors of fatty acid amide hydrolase (FAAH) increase endogenous levels of anandamide (a cannabinoid CB(1)-receptor ligand) and oleoylethanolamide and palmitoylethanolamide (OEA and PEA, ligands for alpha-type peroxisome proliferator-activated nuclear receptors, PPAR-alpha) when and where they are naturally released in the brain. Using a passive-avoidance task in rats, we found that memory acquisition was enhanced by the FAAH inhibitor URB597 or by the PPAR-alpha agonist WY14643, and these… CONTINUE READING
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Peroxisome proliferator - activated receptor a activators improve insulin sensitivity and reduce adiposity

  • J. Haller, I. Barna, +4 authors S. R. Goldberg
  • J . Biol . Chem .
  • 2009
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