Fatty acid amide hydrolase: a gate-keeper of the endocannabinoid system.

  title={Fatty acid amide hydrolase: a gate-keeper of the endocannabinoid system.},
  author={Filomena Fezza and Chiara De Simone and Daniele Amadio and Mauro Maccarrone},
  journal={Sub-cellular biochemistry},
The family of endocannabinoids contains several polyunsaturated fatty acid amides such as anandamide (AEA), but also esters such as 2-arachidonoylglycerol (2-AG). These compounds are the main endogenous agonists of cannabinoid receptors, able to mimic several pharmacological effects of Delta9-tetrahydrocannabinol (Delta9-THC), the active principle of Cannabis sativa preparations like hashish and marijuana. The activity of AEA at its receptors is limited by cellular uptake, through a putative… CONTINUE READING


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