Fatty acid amide hydrolase: a gate-keeper of the endocannabinoid system.

@article{Fezza2008FattyAA,
  title={Fatty acid amide hydrolase: a gate-keeper of the endocannabinoid system.},
  author={Filomena Fezza and Chiara De Simone and Daniele Amadio and Mauro Maccarrone},
  journal={Sub-cellular biochemistry},
  year={2008},
  volume={49},
  pages={101-32}
}
The family of endocannabinoids contains several polyunsaturated fatty acid amides such as anandamide (AEA), but also esters such as 2-arachidonoylglycerol (2-AG). These compounds are the main endogenous agonists of cannabinoid receptors, able to mimic several pharmacological effects of Delta9-tetrahydrocannabinol (Delta9-THC), the active principle of Cannabis sativa preparations like hashish and marijuana. The activity of AEA at its receptors is limited by cellular uptake, through a putative… CONTINUE READING

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References

Publications referenced by this paper.
Showing 1-10 of 151 references

Structure and function of fatty acid amide hydrolase.

Annual review of biochemistry • 2005
View 9 Excerpts
Highly Influenced

The molecular logic of endocannabinoid signalling

Nature Reviews Neuroscience • 2003
View 4 Excerpts
Highly Influenced

Molecular characterization of human and mouse fatty acid amide hydrolases.

Proceedings of the National Academy of Sciences of the United States of America • 1997
View 5 Excerpts
Highly Influenced

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