Fatty acid acylation regulates trafficking of the unusual Plasmodium falciparum calpain to the nucleolus

@inproceedings{Russo2009FattyAA,
  title={Fatty acid acylation regulates trafficking of the unusual Plasmodium falciparum calpain to the nucleolus},
  author={Ilaria Russo and Anna Oksman and Daniel E Goldberg},
  booktitle={Molecular microbiology},
  year={2009}
}
The Plasmodium falciparum genome encodes a single calpain. By generating P. falciparum clones expressing C-terminally tagged calpain, we localized this protein to the nucleolus. Pf_calpain possesses an unusual and long N-terminal domain in which we identified three subregions that are highly conserved among Plasmodium species. Two have putative targeting signals: a myristoylation motif and a nuclear localization sequence. We assessed their functionality. Our data show that the nuclear… CONTINUE READING