Fatty acid DSF binds and allosterically activates histidine kinase RpfC of phytopathogenic bacterium Xanthomonas campestris pv. campestris to regulate quorum-sensing and virulence

@inproceedings{Cai2017FattyAD,
  title={Fatty acid DSF binds and allosterically activates histidine kinase RpfC of phytopathogenic bacterium Xanthomonas campestris pv. campestris to regulate quorum-sensing and virulence},
  author={Zhen Cai and Zhi-hui Yuan and Huan Zhang and Yue Pan and Yao Wu and Xiu-Qi Tian and Fang-fang Wang and Li Wang and Wei Qian},
  booktitle={PLoS pathogens},
  year={2017}
}
As well as their importance to nutrition, fatty acids (FA) represent a unique group of quorum sensing chemicals that modulate the behavior of bacterial population in virulence. However, the way in which full-length, membrane-bound receptors biochemically detect FA remains unclear. Here, we provide genetic, enzymological and biophysical evidences to demonstrate that in the phytopathogenic bacterium Xanthomonas campestris pv. campestris, a medium-chain FA diffusible signal factor (DSF) binds… CONTINUE READING

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