Fatty Acids Prevent Hypoxia-Inducible Factor-1α Signaling Through Decreased Succinate in Diabetes

@inproceedings{Dodd2018FattyAP,
  title={Fatty Acids Prevent Hypoxia-Inducible Factor-1α Signaling Through Decreased Succinate in Diabetes},
  author={Michael S. Dodd and Maria da Luz Sousa Fialho and Claudia N. Montes Aparicio and Matthew Kerr and Kerstin N Timm and Julian Leether Griffin and Joost J. F. P. Luiken and Jan F. C. Glatz and Damian J Tyler and Lisa C. Heather},
  booktitle={JACC. Basic to translational science},
  year={2018}
}
Hypoxia-inducible factor (HIF)-1α is essential following a myocardial infarction (MI), and diabetic patients have poorer prognosis post-MI. Could HIF-1α activation be abnormal in the diabetic heart, and could metabolism be causing this? Diabetic hearts had decreased HIF-1α protein following ischemia, and insulin-resistant cardiomyocytes had decreased HIF-1α-mediated signaling and adaptation to hypoxia. This was due to elevated fatty acid (FA) metabolism preventing HIF-1α protein stabilization… CONTINUE READING

From This Paper

Figures, tables, and topics from this paper.
1 Citations
36 References
Similar Papers

Citations

Publications citing this paper.

References

Publications referenced by this paper.
Showing 1-10 of 36 references

Similar Papers

Loading similar papers…