Fatty Acid Oxidation is Impaired in An Orthologous Mouse Model of Autosomal Dominant Polycystic Kidney Disease.

@article{Menezes2016FattyAO,
  title={Fatty Acid Oxidation is Impaired in An Orthologous Mouse Model of Autosomal Dominant Polycystic Kidney Disease.},
  author={Luis F Menezes and Cheng-Chao Lin and Fang Zhou and Gregory G Germino},
  journal={EBioMedicine},
  year={2016},
  volume={5},
  pages={183-92}
}
BACKGROUND The major gene mutated in autosomal dominant polycystic kidney disease was first identified over 20 years ago, yet its function remains poorly understood. We have used a systems-based approach to examine the effects of acquired loss of Pkd1 in adult mouse kidney as it transitions from normal to cystic state. METHODS We performed transcriptional profiling of a large set of male and female kidneys, along with metabolomics and lipidomics analyses of a subset of male kidneys. We also… CONTINUE READING
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