Fatty Acid Oxidation-Driven Src Links Mitochondrial Energy Reprogramming and Oncogenic Properties in Triple-Negative Breast Cancer.

@article{Park2016FattyAO,
  title={Fatty Acid Oxidation-Driven Src Links Mitochondrial Energy Reprogramming and Oncogenic Properties in Triple-Negative Breast Cancer.},
  author={Jun Hyoung Park and Sajna Antony Vithayathil and Santosh Kumar and P L Sung and Lacey Elizabeth Dobrolecki and Vasanta Putluri and Vadiraja B. Bhat and Salil Kumar Bhowmik and Vineet K. Gupta and Kavisha Arora and Danli Wu and Efrosini Tsouko and Yiqun Zhang and Suman Maity and Taraka R. Donti and Brett H Graham and Daniel E. Frigo and Cristian Coarfa and Patricia Yotnda and Nagireddy Putluri and Arun Sreekumar and Michael T. Lewis and Chad J Creighton and L. J. C. Wong and Benny Abraham Kaipparettu},
  journal={Cell reports},
  year={2016},
  volume={14 9},
  pages={2154-2165}
}
Transmitochondrial cybrids and multiple OMICs approaches were used to understand mitochondrial reprogramming and mitochondria-regulated cancer pathways in triple-negative breast cancer (TNBC). Analysis of cybrids and established breast cancer (BC) cell lines showed that metastatic TNBC maintains high levels of ATP through fatty acid β oxidation (FAO) and activates Src oncoprotein through autophosphorylation at Y419. Manipulation of FAO including the knocking down of carnitine… CONTINUE READING
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