Fatty Acid-Based Strategy for Efficient Brain Targeted Gene Delivery

@article{Shen2013FattyAS,
  title={Fatty Acid-Based Strategy for Efficient Brain Targeted Gene Delivery},
  author={Jie Shen and Mei Yu and Qinggang Meng and Jin Li and Yifan Lv and Weiyue Lu},
  journal={Pharmaceutical Research},
  year={2013},
  volume={30},
  pages={2573-2583}
}
To investigate a fatty acid-based strategy for efficient brain targeted gene delivery and to understand mechanism(s) of this small molecule-mediated brain gene delivery strategy. A series of fatty acids (FAs) were conjugated with polyethylenimine (PEI25k). A near-infrared fluorescence probe, IR820, was used to study in vivo and ex vivo brain targeting ability of these fatty acid-PEI conjugates (FA-PEIs). Brain uptake of FA-PEI25k/rhodamine-6-isothiocyanate (RITC)-labeled DNA nanoparticles was… CONTINUE READING

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