Fatty Acid Availability Sets Cell Envelope Capacity and Dictates Microbial Cell Size

@article{Vadia2017FattyAA,
  title={Fatty Acid Availability Sets Cell Envelope Capacity and Dictates Microbial Cell Size},
  author={Stephen Vadia and Jessica L. Tse and Rafael Lucena and Zhizhou Yang and Douglas R. Kellogg and Jue D. Wang and Petra Anne Levin},
  journal={Current Biology},
  year={2017},
  volume={27},
  pages={1757-1767.e5}
}
Nutrients-and by extension biosynthetic capacity-positively impact cell size in organisms throughout the tree of life. In bacteria, cell size is reduced 3-fold in response to nutrient starvation or accumulation of the alarmone ppGpp, a global inhibitor of biosynthesis. However, whether biosynthetic capacity as a whole determines cell size or whether particular anabolic pathways are more important than others remains an open question. Here we identify fatty acid synthesis as the primary… CONTINUE READING
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