Fatigue in primary Sjögren’s syndrome – A link to sickness behaviour in animals?

@article{Harboe2009FatigueIP,
  title={Fatigue in primary Sj{\"o}gren’s syndrome – A link to sickness behaviour in animals?},
  author={E. G. Harboe and Anne Bolette Tjensvoll and Hege K. Vefring and Lasse Gunnar G{\o}ransson and Jan Terje Kval{\o}y and Roald Omdal},
  journal={Brain, Behavior, and Immunity},
  year={2009},
  volume={23},
  pages={1104-1108}
}
Interleukin-1 Inhibition and Fatigue in Primary Sjögren's Syndrome – A Double Blind, Randomised Clinical Trial
TLDR
This randomised, double-blind, placebo-controlled trial of IL-1 blockade did not find a significant reduction in fatigue in pSS in its primary endpoint, although not supported by the primary endpoint.
Fatigue in primary Sjögren's syndrome is associated with lower levels of proinflammatory cytokines
TLDR
A regression model predicting fatigue levels in pSS based on cytokine levels, disease-specific and clinical parameters, as well as anxiety, pain and depression, revealed IP-10, IFN-γ and interferon-γ-induced protein-10 as the most important predictors of fatigue.
A five-year prospective study of fatigue in primary Sjögren's syndrome
TLDR
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TLDR
A functional network in which several IL-1β-related molecules in CSF influence fatigue in addition to the classical clinical factors of depression and pain is indicated.
Understanding Fatigue in Sjögren’s Syndrome: Outcome Measures, Biomarkers and Possible Interventions
TLDR
The mechanisms involved with fatigue in SS are still poorly understood, but it appears fatigue signaling pathways are more associated with cell protection and defense than with pro-inflammatory pathways.
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TLDR
An overlapping FM can contribute to, but does not entirely account for fatigue in Italian patients with primary Sjögren's syndrome.
Fatigue in primary Sjögren’s syndrome: A proteomic pilot study of cerebrospinal fluid
TLDR
Cerebrospinal fluid proteins and their interacting protein networks may have central roles in the generation and regulation of fatigue, and the findings contribute with evidence to the concept of fatigue as a biological phenomenon signaled through specific molecular pathways.
Pain and fatigue in primary Sjögren's syndrome.
TLDR
How the biology of pain and fatigue influence each other, and act with the overarching purpose of defending the organism against harm and danger, is described.
Salivary IL-1ß as an Objective Measure for Fatigue in Multiple Sclerosis?
TLDR
The present study points to a significant relation between the proinflammatory cytokine IL-1ß and fatigue in relapsing remitting MS patients and suggests a potential effect of disease modifying treatment on the peripheral IL- 1ß concentration.
Interleukin-1 as a mediator of fatigue in disease: a narrative review
TLDR
This narrative review aims to improve the understanding of fatigue in both inflammatory and non-inflammatory illnesses, which could help develop strategies to treat fatigue more effectively.
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The NHP, VAS and SF‐36 are useful in identifying fatigue inThese rheumatic disorders and further work is required to identify the characteristic features of fatigue in these conditions.
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This study compared measures of disease behavior and fatigue symptoms in eight RA patients before and at three time points during treatment with daily administration of anakinra to hypothesized that fatigue in patients with RA might be comparable to sickness behavior in animals possibly caused by disturbances in interleukin-1 beta signaling pathways and thus accessible to blockade by biologic agents.
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To prevent the loss in diagnosis of pSS, the addition of ANA, RF, and tear break‐up time (BUT) tests to US‐EU criteria would be appropriate.
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TLDR
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TLDR
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