Invited review Clinical neurophysiology of fatigue
- Psychology, Medicine
Although it seems to be a universal symptom of many brain disorders, the unique characteristics of the concomitant fatigue also point to a specific relationship with several of these syndromes.
Neural Dysfunction in Chronic Fatigue Syndrome
- Psychology, Biology
Data from behavioral, electrophysiological, and neuroimaging experiments related to neural dysfunction in CFS suggest that the central nervous system is primarily involved in the pathophysiology of CFS and proposes a treatment strategy on the basis of these suggested underlying neural mechanisms.
Fatigue in neuromuscular disorders: focus on Guillain–Barré syndrome and Pompe disease
- Psychology, MedicineCellular and Molecular Life Sciences
Treatment of fatigue in neuromuscular disease starts with symptomatic treatment of the underlying disease, and non-pharmacological interventions, such as exercise and cognitive behavioral therapy, can be initiated.
Fatigue in Multiple Sclerosis: General and Perceived Fatigue Does Not Depend on Corticospinal Tract Dysfunction
- Psychology, MedicineFront. Neurol.
In MS patients the pathogenesis of fatigue seems not driven by the mechanisms directly related to corticospinal function (that characterize fatigue in controls) but seems probably due to other “central abnormalities” upstream to primary motor cortex.
Fatigue, Sleep, and Autoimmune and Related Disorders
- Biology, MedicineFront. Immunol.
How inflammation and the central nervous system contribute to fatigue is described and potential mechanisms involved in fatigue that are likely exhibited in autoimmune and related diseases are suggested.
Frontier studies on fatigue, autonomic nerve dysfunction, and sleep-rhythm disorder
- Psychology, MedicineThe Journal of Physiological Sciences
Data is reviewed primarily from behavioral, electrophysiological, and neuroimaging experiments related to neural dysfunction as well as autonomic nervous system, sleep, and circadian rhythm disorders in fatigue to provide new perspectives on the mechanisms underlying chronic fatigue and on overcoming it.
Experienced and physiological fatigue in neuromuscular disorders
- MedicineClinical Neurophysiology
Understanding fatigue in multiple sclerosis
- Psychology, Medicine
It is suggested that fatigue may be multifactorial in origin as the evidence does not strongly support any one causal mechanism.
Central Autonomic Network Disturbance in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Pilot Study
Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a debilitating disease of the central nervous system known to be associated with multiple behavioral symptoms (fatigue, low stamina,…
SHOWING 1-10 OF 107 REFERENCES
Neurological Dysfunction in Chronic Fatigue Syndrome
- Medicine, Psychology
Ion channel abnormality leading to neuronal instability in selective anatomical pathways (basal ganglia circuitry) is proposed as the possible mechanism of fluctuating fatigue and related symptoms in CFS.
Fatigue after Stroke: A Major but Neglected Issue
- Psychology, BiologyCerebrovascular Diseases
The concept of ‘primary’ poststroke fatigue is emphasized, which may develop in the absence of depression or a significant cognitive sequela, and which may be linked to attentional deficits resulting from specific damage to the reticular formation and related structures involved in the subcortical attentional network.
Parallels between post-polio fatigue and chronic fatigue syndrome: a common pathophysiology?
- Medicine, PsychologyThe American journal of medicine
The Chronic Fatigue Syndrome: A Comprehensive Approach to Its Definition and Study
- Medicine, PsychologyAnnals of Internal Medicine
We have developed a conceptual framework and a set of research guidelines for use in studies of the chronic fatigue syndrome. The guidelines cover the clinical and laboratory evaluation of persons…
Fatigue in immune-mediated polyneuropathies
- Medicine, PsychologyNeurology
Fatigue is a major symptom in patients with immune-mediated polyneuropathies and may persist for years after apparent recovery and the Fatigue Severity Scale seems appropriate for assessing fatigue in these patients because good internal consistency, reliability, and validity were demonstrated.
Proton magnetic resonance spectroscopy of basal ganglia in chronic fatigue syndrome
- Medicine, PsychologyNeuroreport
In the absence of regional structural or inflammatory pathology, increased choline resonance in CFS may be an indicator of higher cell membrane turnover due to gliosis or altered intramembrane signalling.
Poliomyelitis and the post-polio syndrome: exercise capacities and adaptation--current research, future directions, and widespread applicability.
- MedicineMedicine and science in sports and exercise
The purpose of this paper is to review post-polio syndrome (PPS) as well as the effect of exercise on the symptoms and morphologic adaptations to PPS and where future research efforts should be directed.
The fatigue severity scale. Application to patients with multiple sclerosis and systemic lupus erythematosus.
- Psychology, MedicineArchives of neurology
A fatigue severity scale was internally consistent, correlated well with visual analogue measures, clearly differentiated controls from patients, and could detect clinically predicted changes in fatigue over time and identify features that distinguish fatigue between two chronic medical disorders.