Fatigue in neurological disorders

@article{Chaudhuri2004FatigueIN,
  title={Fatigue in neurological disorders},
  author={Abhijit Chaudhuri and Peter O. Behan},
  journal={The Lancet},
  year={2004},
  volume={363},
  pages={978-988}
}
View on Elsevier
doi.org
1,003 Citations
Highly Influential Citations
56
Background Citations
455
Methods Citations
23
Results Citations
16

Figures from this paper

1,003 Citations

Clinical neurophysiology of fatigue
Invited review Clinical neurophysiology of fatigue
TLDR
Although it seems to be a universal symptom of many brain disorders, the unique characteristics of the concomitant fatigue also point to a specific relationship with several of these syndromes.
Neural Dysfunction in Chronic Fatigue Syndrome
TLDR
Data from behavioral, electrophysiological, and neuroimaging experiments related to neural dysfunction in CFS suggest that the central nervous system is primarily involved in the pathophysiology of CFS and proposes a treatment strategy on the basis of these suggested underlying neural mechanisms.
Fatigue in neuromuscular disorders: focus on Guillain–Barré syndrome and Pompe disease
TLDR
Treatment of fatigue in neuromuscular disease starts with symptomatic treatment of the underlying disease, and non-pharmacological interventions, such as exercise and cognitive behavioral therapy, can be initiated.
Fatigue in Multiple Sclerosis: General and Perceived Fatigue Does Not Depend on Corticospinal Tract Dysfunction
TLDR
In MS patients the pathogenesis of fatigue seems not driven by the mechanisms directly related to corticospinal function (that characterize fatigue in controls) but seems probably due to other “central abnormalities” upstream to primary motor cortex.
Fatigue, Sleep, and Autoimmune and Related Disorders
TLDR
How inflammation and the central nervous system contribute to fatigue is described and potential mechanisms involved in fatigue that are likely exhibited in autoimmune and related diseases are suggested.
Frontier studies on fatigue, autonomic nerve dysfunction, and sleep-rhythm disorder
TLDR
Data is reviewed primarily from behavioral, electrophysiological, and neuroimaging experiments related to neural dysfunction as well as autonomic nervous system, sleep, and circadian rhythm disorders in fatigue to provide new perspectives on the mechanisms underlying chronic fatigue and on overcoming it.
Experienced and physiological fatigue in neuromuscular disorders
Understanding fatigue in multiple sclerosis
TLDR
It is suggested that fatigue may be multifactorial in origin as the evidence does not strongly support any one causal mechanism.
Central Autonomic Network Disturbance in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Pilot Study
Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a debilitating disease of the central nervous system known to be associated with multiple behavioral symptoms (fatigue, low stamina,…
...
...

References

SHOWING 1-10 OF 107 REFERENCES
Neurological Dysfunction in Chronic Fatigue Syndrome
TLDR
Ion channel abnormality leading to neuronal instability in selective anatomical pathways (basal ganglia circuitry) is proposed as the possible mechanism of fluctuating fatigue and related symptoms in CFS.
Fatigue and basal ganglia
Fatigue after Stroke: A Major but Neglected Issue
TLDR
The concept of ‘primary’ poststroke fatigue is emphasized, which may develop in the absence of depression or a significant cognitive sequela, and which may be linked to attentional deficits resulting from specific damage to the reticular formation and related structures involved in the subcortical attentional network.
Parallels between post-polio fatigue and chronic fatigue syndrome: a common pathophysiology?
The Chronic Fatigue Syndrome: A Comprehensive Approach to Its Definition and Study
We have developed a conceptual framework and a set of research guidelines for use in studies of the chronic fatigue syndrome. The guidelines cover the clinical and laboratory evaluation of persons…
Fatigue and sarcoidosis.
  • O. Sharma
  • Medicine
    The European respiratory journal
  • 1999
Fatigue in immune-mediated polyneuropathies
TLDR
Fatigue is a major symptom in patients with immune-mediated polyneuropathies and may persist for years after apparent recovery and the Fatigue Severity Scale seems appropriate for assessing fatigue in these patients because good internal consistency, reliability, and validity were demonstrated.
Proton magnetic resonance spectroscopy of basal ganglia in chronic fatigue syndrome
TLDR
In the absence of regional structural or inflammatory pathology, increased choline resonance in CFS may be an indicator of higher cell membrane turnover due to gliosis or altered intramembrane signalling.
Poliomyelitis and the post-polio syndrome: exercise capacities and adaptation--current research, future directions, and widespread applicability.
  • T. Birk
  • Medicine
    Medicine and science in sports and exercise
  • 1993
TLDR
The purpose of this paper is to review post-polio syndrome (PPS) as well as the effect of exercise on the symptoms and morphologic adaptations to PPS and where future research efforts should be directed.
The fatigue severity scale. Application to patients with multiple sclerosis and systemic lupus erythematosus.
TLDR
A fatigue severity scale was internally consistent, correlated well with visual analogue measures, clearly differentiated controls from patients, and could detect clinically predicted changes in fatigue over time and identify features that distinguish fatigue between two chronic medical disorders.
...
...