Fatigue in multiple sclerosis: definition, pathophysiology and treatment.

  title={Fatigue in multiple sclerosis: definition, pathophysiology and treatment.},
  author={Lauren B. Krupp},
  journal={CNS drugs},
  volume={17 4},
Fatigue is a common disabling symptom of multiple sclerosis (MS). It is often considered a state of exhaustion distinct from depressed mood or physical weakness. Fatigue can be assessed by either self-report scales or performance-based measures; however, neither method captures all features of fatigue. Fatigue in MS frequently leads to unemployment. It is associated with a sense of loss of control over one's environment, low positive affect, psychological distress and neurological impairment… CONTINUE READING

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