Fatigue and pruritus at onset identify a more aggressive subset of primary biliary cirrhosis.

@article{Quarneti2015FatigueAP,
  title={Fatigue and pruritus at onset identify a more aggressive subset of primary biliary cirrhosis.},
  author={Chiara Quarneti and Paolo Muratori and Claudine Lalanne and Angela Fabbri and Rita Menichella and A Granito and Chiara Masi and Marco Lenzi and Fabio Cassani and Georgios M Pappas and Luigi Muratori},
  journal={Liver international : official journal of the International Association for the Study of the Liver},
  year={2015},
  volume={35 2},
  pages={636-41}
}
BACKGROUND & AIMS In recent years, primary biliary cirrhosis is mostly diagnosed in patients who are asymptomatic; however, a proportion of cases still present with typical complaints such as fatigue and/or pruritus. We compared biochemical, histological and immunological features of patients with or without fatigue and/or pruritus at onset to see whether the different clinical presentation may eventually impact on disease progression. METHODS We analysed the Bologna cohort of 216 patients… CONTINUE READING

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