Fatigue and heat production in repeated contractions of mouse skeletal muscle.

  title={Fatigue and heat production in repeated contractions of mouse skeletal muscle.},
  author={Christopher J Barclay and Prof. Dr. rer. nat. N. Arnold and Colin L. Gibbs},
  journal={The Journal of physiology},
  volume={488 ( Pt 3)},
1. This study tested the hypothesis that moderate fatigue of skeletal muscle arises from a mismatch between energy demand and energy supply. Fatigue was defined as the decline in isometric force. Energy supply and demand were assessed from measurements of muscle heat production. 2. Experiments were performed in vitro (21 degrees C) with bundles of muscle fibres from mouse fast-twitch extensor digitorum longus muscle and slow-twitch soleus muscle. Fibre bundles were fatigued using a series of… CONTINUE READING
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