Fatigue and cognitive function in systemic lupus erythematosus: associations with white matter microstructural damage. A diffusion tensor MRI study and meta-analysis.

@article{Wiseman2017FatigueAC,
  title={Fatigue and cognitive function in systemic lupus erythematosus: associations with white matter microstructural damage. A diffusion tensor MRI study and meta-analysis.},
  author={Stewart J Wiseman and M. E. Bastin and Iona F. Hamilton and David Hunt and S J Ritchie and Esther Nicole Amft and Sarah Thomson and Jill J. F. Belch and S. H. Ralston and Joanna M. Wardlaw},
  journal={Lupus},
  year={2017},
  volume={26 6},
  pages={588-597}
}
Objective The objective of this study was to investigate fatigue and cognitive impairments in systemic lupus erythematous (SLE) in relation to diffuse white matter microstructural brain damage. Methods Diffusion tensor MRI, used to generate biomarkers of brain white matter microstructural integrity, was obtained in patients with SLE and age-matched controls. Fatigue and cognitive function were assessed and related to SLE activity, clinical data and plasma biomarkers of inflammation and… CONTINUE READING
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