author={Per Hartvig Honor{\'e}},
  journal={European Journal of Hospital Pharmacy: Science and Practice},
  pages={147 - 148}
  • P. Hartvig Honoré
  • Published 17 May 2013
  • Psychology
  • European Journal of Hospital Pharmacy: Science and Practice
Fatigue is today the most common and incapacitating side effect in patients with cancer. Fatigue affects both physical and psychosocial function and reduces the patients’ quality of life. It is aggravated with co-morbidities and the presence and severity of other symptoms like pain, insomnia, depression, anxiety, diarrhoea. Risk factors also include female gender and young age. The mechanisms explaining fatigue is still mostly unknown and there is no general treatment to alleviate the symptoms… 


Fatigue in cancer patients treated with cytotoxic drugs
It is verified that fatigue is a common side effect, and affects quality of life negatively, even for outpatients receiving cytotoxic drugs.
Cancer-related fatigue: guidelines for evaluation and management.
Although additional research is needed to further identify the causes and corresponding treatment of fatigue, practitioners should routinely assess and treat patients who may benefit from currently identified interventions, because fatigue can profoundly undermine the quality of life of patients with cancer.
Fatigue associated with cancer and its treatment
Four plausible hypotheses for the development of fatigue are introduced and evidence available to support a role for anemia, adenosine triphosphate, vagal afferents, and the interaction of the HPA/cytokines and 5HT is discussed.
Effects of exercise on cancer‐related fatigue
Cancer patients frequently suffer from fatigue and loss of physical performance. Several biologic, psychologic, and social factors have been suggested as explanations for the origins of fatigue in
Treating fatigue in cancer patients.
Possible causes of cancer-related fatigue include depression, pain, sleep problems, anemia, deconditioning, metabolic abnormalities, infection, dietary problems, hypoxia, and side effects of
Cancer‐related fatigue
A critical appraisal of a standard of care for the assessment or treatment of fatigue in patients with cancer and its physiologic basis remains poorly understood is presented in this review.
Impact of cancer-related fatigue on the lives of patients: new findings from the Fatigue Coalition.
Cancer-related fatigue is common among cancer patients who have received chemotherapy and results in substantial adverse physical, psychosocial, and economic consequences for both patients and caregivers.
Strategies for managing cancer‐related fatigue syndrome
Developing research based clinical interventions in therapeutic exercise training, diet therapy, sleep therapy, cognitive therapy, and pharmacologic therapy hold promise for significant improvement in functioning and quality of life for cancer survivors and may constitute valuable rehabilitative techniques that can be adjunctive to standard therapies.
Patient-controlled methylphenidate for the management of fatigue in patients with advanced cancer: a preliminary report.
  • E. Bruera, L. Driver, C. Escalante
  • Medicine, Psychology
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • 2003
Preliminary results suggest that patient-controlled methylphenidate administration rapidly improved fatigue and other symptoms and Randomized controlled trials are justified.