Fate tracing reveals the endothelial origin of hematopoietic stem cells.


Hematopoietic stem cells (HSCs) originate within the aortic-gonado-mesonephros (AGM) region of the midgestation embryo, but the cell type responsible for their emergence is unknown since critical hematopoietic factors are expressed in both the AGM endothelium and its underlying mesenchyme. Here we employ a temporally restricted genetic tracing strategy to… (More)
DOI: 10.1016/j.stem.2008.09.018


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