Fate of3H- and14C-labelled A-4166 in pancreatic islets


The fate of3H- and14C-labelled A-4166 was examined in rat pancreatic islets. The net uptake of the meglitinide analogue by islets incubated for 60 min in the presence of 0.1 mM A-4166 and then submitted to repeated washes was close to 0.1 pmol/islet. It was significantly increased when the concentration ofd-glucose in the incubation medium was raised from 2… (More)
DOI: 10.1007/BF00571569

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