Fate of water-soluble polymers administered via different routes.

  title={Fate of water-soluble polymers administered via different routes.},
  author={Tetsuji Yamaoka and Yasuhiko Tabata and Yoshito Ikada},
  journal={Journal of pharmaceutical sciences},
  volume={84 3},
The biological fate of synthetic water-soluble polymers administered to mice by injection at different sites is described. After intraperitoneal (ip), subcutaneous (sc), and intramuscular (im) injections of 125I-labeled poly(vinyl alcohol) (PVA) and poly(ethylene glycol) (PEG) with various molecular weights, the time-course of polymer concentration in the blood was measured and analyzed pharmacokinetically. The location of PVA in the body was similar to that of PEG; that is, the elimination… CONTINUE READING

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