Fate of water-soluble polymers administered via different routes.

@article{Yamaoka1995FateOW,
  title={Fate of water-soluble polymers administered via different routes.},
  author={Tetsuji Yamaoka and Yasuhiko Tabata and Yoshito Ikada},
  journal={Journal of pharmaceutical sciences},
  year={1995},
  volume={84 3},
  pages={349-54}
}
The biological fate of synthetic water-soluble polymers administered to mice by injection at different sites is described. After intraperitoneal (ip), subcutaneous (sc), and intramuscular (im) injections of 125I-labeled poly(vinyl alcohol) (PVA) and poly(ethylene glycol) (PEG) with various molecular weights, the time-course of polymer concentration in the blood was measured and analyzed pharmacokinetically. The location of PVA in the body was similar to that of PEG; that is, the elimination… CONTINUE READING

From This Paper

Topics from this paper.

Citations

Publications citing this paper.
Showing 1-10 of 29 extracted citations

Characterisation of aptamers for therapeutic studies.

Expert opinion on drug discovery • 2007
View 17 Excerpts
Highly Influenced

Design of smart HPMA copolymer-based nanomedicines.

Journal of controlled release : official journal of the Controlled Release Society • 2016
View 1 Excerpt

Similar Papers

Loading similar papers…