Fate of teratocarcinoma cells injected into early mouse embryos

@article{PAPAIOANNOU1975FateOT,
  title={Fate of teratocarcinoma cells injected into early mouse embryos},
  author={V. E. PAPAIOANNOU and M. W. MCBURNEY and R. L. GARDNER and M. J. EVANS},
  journal={Nature},
  year={1975},
  volume={258},
  pages={70-73}
}
  • V. E. PAPAIOANNOU, M. W. MCBURNEY, +1 author M. J. EVANS
  • Published in Nature 1975
  • DOI:10.1038/258070a0
ANALYSIS of early mammalian development is complicated by technical difficulties. The initial processes of cellular determination and differentiation in the mouse embryo take place in small populations of cells1,2, and major embryogenic events occur after uterine implantation when the embryo is largely inaccessible. Recent work, however, suggests that murine teratocarcinomas may provide a convenient model for studying mammalian development3–6. These are transplantable tumours of germ cell or… CONTINUE READING
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