Fate of midbrain dopaminergic neurons controlled by the engrailed genes.

@article{Simon2001FateOM,
  title={Fate of midbrain dopaminergic neurons controlled by the engrailed genes.},
  author={Horst H. Simon and Harald Saueressig and Wolfgang Wurst and Martyn D Goulding and D D O'leary},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2001},
  volume={21 9},
  pages={3126-34}
}
Deficiencies in neurotransmitter-specific cell groups in the midbrain result in prominent neural disorders, including Parkinson's disease, which is caused by the loss of dopaminergic neurons of the substantia nigra. We have investigated in mice the role of the engrailed homeodomain transcription factors, En-1 and En-2, in controlling the developmental fate of midbrain dopaminergic neurons. En-1 is highly expressed by essentially all dopaminergic neurons in the substantia nigra and ventral… CONTINUE READING
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