Fate of membrane-bound reactants and products during the activation of human prothrombin by prothrombinase.

@article{Kamath2008FateOM,
  title={Fate of membrane-bound reactants and products during the activation of human prothrombin by prothrombinase.},
  author={Parvathi Kamath and Sriram Krishnaswamy},
  journal={The Journal of biological chemistry},
  year={2008},
  volume={283 44},
  pages={30164-73}
}
Membrane binding by prothrombin, mediated by its N-terminal fragment 1 (F1) domain, plays an essential role in its proteolytic activation by prothrombinase. Thrombin is produced in two cleavage reactions. One at Arg(320) yields the proteinase meizothrombin that retains membrane binding properties. The second, at Arg(271), yields thrombin and severs covalent… CONTINUE READING