Fate of melanoma cells entering the microcirculation: over 80% survive and extravasate.

@article{Koop1995FateOM,
  title={Fate of melanoma cells entering the microcirculation: over 80% survive and extravasate.},
  author={Sahadia Koop and I C Macdonald and Keith J. Luzzi and Eric E. Schmidt and Vincent L. Morris and Marsha Grattan and Rama Khokha and Ann F. Chambers and Alan C. Groom},
  journal={Cancer research},
  year={1995},
  volume={55 12},
  pages={2520-3}
}
Metastasis is an inefficient process; only a few cancer cells are able to form tumors after being released into the circulation. We studied the fate of cancer cells after injection into the circulation, quantifying their survival and ability to extravasate by 1 day later. B16F10 cells, parental or transfectants overexpressing tissue inhibitor of metalloproteinases 1, were injected i.v. into chorioallantoic membrane of chick embryos and analyzed by intravital videomicroscopy. Cell survival was… CONTINUE READING

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