Fate of (D-Ala2)-deltorphin-I-like immunoreactive neurons in 6-hydroxydopamine lesioned rat brain.

@article{Casini2004FateO,
  title={Fate of (D-Ala2)-deltorphin-I-like immunoreactive neurons in 6-hydroxydopamine lesioned rat brain.},
  author={Alessandro F. Casini and Annalisa Pinna and Ikuo Tooyama and Hiroshi Kimura and Gaetano Di Chiara and Tindaro G. Renda},
  journal={European journal of histochemistry : EJH},
  year={2004},
  volume={48 2},
  pages={
          135-40
        }
}
The use of a polyclonal antiserum specific to C-terminal tetrapeptide amide of (D-Ala2)deltorphin-I, a naturally occurring amphibian skin opioid peptide, has already demonstrated the presence of immunoreactive neurons in rat midbrain. Double immunostaining identified these neurons as a subpopulation of the mesencephalic dopaminergic neurons that were also tyrosine hydroxylase-immunopositive and calbindin-D28kD- negative, namely, the neurons predominantly affected in Parkinson disease. We… CONTINUE READING

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