Fate mapping of ptf1a-expressing cells during pancreatic organogenesis and regeneration in zebrafish.

@article{Wang2015FateMO,
  title={Fate mapping of ptf1a-expressing cells during pancreatic organogenesis and regeneration in zebrafish.},
  author={Yue Wang and Joon Tae Park and Michael W. Parsons and Steven D. Leach},
  journal={Developmental dynamics : an official publication of the American Association of Anatomists},
  year={2015},
  volume={244 6},
  pages={724-35}
}
BACKGROUND Pancreas development in zebrafish shares many features with mammals, including the participation of epithelial progenitor cells expressing pancreas transcription factor 1a (ptf1a). However, to date it has remained unclear whether, as in mammals, ptf1a-expressing zebrafish pancreatic progenitors are able to contribute to multiple exocrine and endocrine lineages. To delineate the lineage potential of ptf1a-expressing cells, we generated ptf1a:creER(T2) transgenic fish and performed… CONTINUE READING
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