Fate mapping Nkx2.1-lineage cells in the mouse telencephalon.

  title={Fate mapping Nkx2.1-lineage cells in the mouse telencephalon.},
  author={Qing Xu and Melissa Tam and Stewart A. Anderson},
  journal={The Journal of comparative neurology},
  volume={506 1},
The homeodomain transcription factor Nkx2.1 is expressed in the pallidal (subcortical) telencephalon, including the medial ganglionic eminence (MGE) and preoptic area. Studies have shown that Nkx2.1 is required for normal patterning of the MGE and for the specification of the parvalbumin (PV)- and somatostatin (SST)-expressing cortical interneurons. To define the contribution of Nkx2.1 lineages to neurons in the mature telencephalon, we have generated transgenic mice carrying the genomic… CONTINUE READING
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