Fate and toxic effects of inhaled ultrafine cadmium oxide particles in the rat lung.

@article{Takenaka2004FateAT,
  title={Fate and toxic effects of inhaled ultrafine cadmium oxide particles in the rat lung.},
  author={Shinji Takenaka and Erwin W Karg and Wolfgang G Kreyling and Bernd Lentner and Holger Schulz and Axel Ziesenis and Peter Schramel and Joachim Heyder},
  journal={Inhalation toxicology},
  year={2004},
  volume={16 Suppl 1},
  pages={
          83-92
        }
}
Female Fischer 344 rats were exposed to ultrafine cadmium oxide particles, generated by spark discharging, for 6 h at a concentration of 70 microg Cd/m(3) (1 x 10(6)/cm(3)) (40 nm modal diameter). Lung morphology and quantification of Cd content/concentration by inductively coupled plasma (ICP)-mass spectrometry were performed on days 0, 1, 4, and 7 after exposure. Cd content in the lung on day 0 was 0.53 +/- 0.12 microg/lung, corresponding to 19% of the estimated total inhaled cumulative dose… CONTINUE READING
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