Fate alteration of neuroepithelial cells from neurogenesis to astrocytogenesis by bone morphogenetic proteins.

@article{Yanagisawa2001FateAO,
  title={Fate alteration of neuroepithelial cells from neurogenesis to astrocytogenesis by bone morphogenetic proteins.},
  author={M. D. K. Yanagisawa and Takumi Takizawa and Wataru Ochiai and Atsumi Uemura and Kinichi Nakashima and Tetsuya Taga},
  journal={Neuroscience research},
  year={2001},
  volume={41 4},
  pages={391-6}
}
Bone morphogenetic proteins (BMPs), a class of cytokines belonging to the transforming growth factor-beta superfamily, have been shown to play a wide variety of roles during development including those in the central nervous system. We here report that BMP2, BMP4 and BMP7 have an equivalent potential to inhibit neurogenesis and concomitantly induce astrocytogenesis of mouse fetal neuroepithelial cells. We further show that these BMPs activate a promoter of the gene for negative helix-loop-helix… CONTINUE READING