Fatality in mice due to oversaturation of cellular microRNA/short hairpin RNA pathways

@article{Grimm2006FatalityIM,
  title={Fatality in mice due to oversaturation of cellular microRNA/short hairpin RNA pathways},
  author={Dirk Grimm and Konrad L. Streetz and Catherine L. Jopling and Theresa A. Storm and Kusum Lata Pandey and Corrine R. Davis and Patricia L. Marion and Felix H. Salazar and Mark A. Kay},
  journal={Nature},
  year={2006},
  volume={441},
  pages={537-541}
}
RNA interference (RNAi) is a universal and evolutionarily conserved phenomenon of post-transcriptional gene silencing by means of sequence-specific mRNA degradation, triggered by small double-stranded RNAs. Because this mechanism can be efficiently induced in vivo by expressing target-complementary short hairpin RNA (shRNA) from non-viral and viral vectors, RNAi is attractive for functional genomics and human therapeutics. Here we systematically investigate the long-term effects of sustained… 

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