Fatality from acute chlorfenapyr poisoning

@article{Choi2010FatalityFA,
  title={Fatality from acute chlorfenapyr poisoning},
  author={Jung Tae Choi and Gu Hyun Kang and Yong Soo Jang and Hee Cheol Ahn and Jeong Youl Seo and You Dong Sohn},
  journal={Clinical Toxicology},
  year={2010},
  volume={48},
  pages={458 - 459}
}
Chlorfenapyr [4-bromo-2-(4-chlorophenyl)-1-(ethoxymethyl)5-(trifluoromethyl)-1H-pyrrole-3-carbonitrile; trade name is the Pylon Miticide-Insecticide, Pirate, etc.] is used to control a number of cotton pests. It interferes with mitochondrial oxidative phosphorylation, resulting in disruption of ATP production and cellular death. In animal studies, its acute oral LD50 was 626 mg/kg in rat and 55 mg/kg in mouse. 2 Its registration for use on cotton was denied by the United States Environmental… 
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14 Citations

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Citation Type

Who is the real killer? Chlorfenapyr or detergent micelle-chlorfenapyr complex?
TLDR
The combination of chlorfenapyr and detergent, a deadly cocktail to form micelle complex that can greatly influence bioavailability by attaching to biological membranes in vivo, causes the fatality in suicidal attempts using chlorfenAPyr.
A fatal case of chlorfenapyr poisoning following dermal exposure
TLDR
A case of chlorfenapyr intoxication after skin exposure in a 49-year-old patient who died 5 days after exposure demonstrates that similar to oral ingestion, dermal absorption of chlor Fenapyr may also be fatal.
Toxicity from Intra-Abdominal Injection of Chlorfenapyr
TLDR
This is the first reported case of intra-abdominal injection of chlorfenapyr, commonly used for food crops in Korea, which resulted in an ischemic change in the small intestine, eventually leading to sepsis and death.
Acute chlorfenapyr toxicity in 3 dogs from a single household.
TLDR
This is the first reported case of chlorfenapyr toxicity in dogs and previous case reports in human medicine have reported a variable mortality rate, although 1 of 3 dogs described here made a complete recovery.
A Case of Chlorfenapyr Intoxication with Central Nervous SystemInvolvement
TLDR
It is presumed Chlorfenapyr or its metabolite can induced delayed neurotoxicity in the central nervous system and brain Magnetic resonance imaging (MRI) showed extensive bilateral involvement of the white matter.
Brain damage caused by chlorfenapyr poisoning: a case report and literature review
TLDR
A 15-year-old female who swallowed 10 mL of 10%chlorfenapyr, and was subjected to gastric lavage one hour after ingestion died on the fourth day because of central fever, brain hernia, and brain dysfunction.
Delayed hyperthermia from chlorfenapyr overdose
A case of survival after chlorfenapyr intoxication with acute pancreatitis
TLDR
A 61-year-old woman brought to the emergency department with vomiting after ingesting 10 mL chlorfenapyr in a suicide attempt 1 hour before was transferred to the intensive care unit, where she improved with conservative care and was discharged to home 19 days after admission.
Toxicity of the Chlorfenapyr: Growth inhibition and induction of oxidative stress on a freshwater protozoan: Paramecium sp.
TLDR
The inhibitory effect of a newly synthesized acaricide, chlorfenapyr, is investigated on a pure culture of Paramecium sp.
Chlorfenapyr-Induced Toxic Leukoencephalopathy with Radiologic Reversibility: A Case Report and Literature Review
TLDR
The first non-fatal case of chlorfenapyr-induced toxic leukoencephalopathy in a 44-year-old female with resolution of extensive and abnormal signal intensities in white matter tracts throughout the brain, brain stem, and spinal cord on serial magnetic resonance imaging is reported.
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Sheet
  • EPA-730-F-00-001;
  • 2001
of Registration of Chlorfenapyr for Use on Cotton
  • Washington, DC 20460;
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