Fatalities Temporally Associated with the Ingestion of Ibogaine

  title={Fatalities Temporally Associated with the Ingestion of Ibogaine},
  author={Kenneth Alper and Marina Staji{\'c} and James R. Gill},
  journal={Journal of Forensic Sciences},
Abstract:  Ibogaine is a naturally occurring psychoactive plant alkaloid that is used globally in medical and nonmedical settings for opioid detoxification and other substance use indications. All available autopsy, toxicological, and investigative reports were systematically reviewed for the consecutive series of all known fatalities outside of West Central Africa temporally related to the use of ibogaine from 1990 through 2008. Nineteen individuals (15 men, four women between 24 and 54 years… 

Life-threatening complications of ibogaine: three case reports.

It is of great importance that clinicians are aware of these potentially serious side effects and realise that widespread online marketing practices will give many more people access to ibogaine.

Death due to consumption of ibogaine: case report

Data suggest that death, which occurred unnaturally after initiation of the “treatment”, was probably the result of the cardiovascular effects caused by the ibogaine powder, which had been bought online and used in the process of detoxification during an addiction treatment.

Ibogaine-associated cardiac arrest and death: case report and review of the literature

A 40-year-old man who used ibogaine for symptoms of heroin withdrawal suffered acute cardiac arrest leading to cerebral edema and brain death, and a review of the literature regarding the history, mechanisms, risks and clinical outcomes associated with Ibogaine is presented.

Treating drug dependence with the aid of ibogaine: A retrospective study

A retrospective analysis of data from 75 previous alcohol, cannabis, cocaine and crack users suggests that ibogaine can be a safe and effective treatment for dependence on stimulant and other non-opiate drugs.

Mania following use of ibogaine: A case series.

Clinicians are advised to be prepared for discussing the safety, efficacy, and paucity of good data regarding ibogaine with patients who may be considering its use, and to benefit from careful substance use and treatment history, specifically regarding opiates.

Safety of ibogaine administration in detoxification of opioid dependent individuals: a descriptive open-label observational study.

This open‐label observational study found that ibogaine treatment of patients with opioid use disorder can induce a clinically relevant but reversible QTc prolongation, bradycardia, and severe ataxia.

The adverse events of ibogaine in humans: an updated systematic review of the literature (2015-2020).

There is a high need of phase I clinical trials that can describe the safety of different dosages of ibogaine with standardized products, and clinical profiling of vulnerable populations is performed.



Ibogaine and the inhibition of acetylcholinesterase.

Treatment of acute opioid withdrawal with ibogaine.

The reported effectiveness of ibogaine in this series suggests the need for systematic investigation in a conventional clinical research setting.

Bioanalytical and clinical evaluation of 103 suspected cases of intoxications with psychoactive plant materials

The patients using psychoactive plant materials were mainly young and commonly used the Internet for drug acquisition and having access to bioanalytical methods for detection of plant-derived psychoactives is considered important, when providing clinical toxicology service.

Distribution of ibogaine and noribogaine in a man following a poisoning involving root bark of the Tabernanthe iboga shrub.

The tissue distribution of ibogaine and noribogaine, the main metabolite of ibogsaine, in a 48-year-old Caucasian male found dead at his home after a poisoning involving the ingestion of root bark from the shrub Tabernanthe iboga is reported.

Medication development of ibogaine as a pharmacotherapy for drug dependence.

A rising tolerance study using single administration of ibogaine for treatment of cocaine dependency is initiated to determine safety, pharmacokinetics and dose effects, and to identify relevant parameters of efficacy in cocaine-dependent patients.

The ibogaine medical subculture.

Ibogaine: a review.

  • K. Alper
  • Biology
    The Alkaloids. Chemistry and biology
  • 2001

Effects of 18‐methoxycoronaridine on acute signs of morphine withdrawal in rats

18-Methoxycoronaridine (18-MC), a novel iboga alkaloid congener, has been shown, in animals, to mimic the effects of ibogaine on morphine self-administration without producing any ibogane-like neurotoxiticity.