Fatalities Temporally Associated with the Ingestion of Ibogaine

@article{Alper2012FatalitiesTA,
  title={Fatalities Temporally Associated with the Ingestion of Ibogaine},
  author={Kenneth Alper and Marina Staji{\'c} and James R. Gill},
  journal={Journal of Forensic Sciences},
  year={2012},
  volume={57}
}
Abstract:  Ibogaine is a naturally occurring psychoactive plant alkaloid that is used globally in medical and nonmedical settings for opioid detoxification and other substance use indications. All available autopsy, toxicological, and investigative reports were systematically reviewed for the consecutive series of all known fatalities outside of West Central Africa temporally related to the use of ibogaine from 1990 through 2008. Nineteen individuals (15 men, four women between 24 and 54 years… 
Ibogaine related sudden death: a case report.
TLDR
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TLDR
It is of great importance that clinicians are aware of these potentially serious side effects and realise that widespread online marketing practices will give many more people access to ibogaine.
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TLDR
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TLDR
Data suggest that death, which occurred unnaturally after initiation of the “treatment”, was probably the result of the cardiovascular effects caused by the ibogaine powder, which had been bought online and used in the process of detoxification during an addiction treatment.
Ibogaine-associated cardiac arrest and death: case report and review of the literature
TLDR
A 40-year-old man who used ibogaine for symptoms of heroin withdrawal suffered acute cardiac arrest leading to cerebral edema and brain death, and a review of the literature regarding the history, mechanisms, risks and clinical outcomes associated with Ibogaine is presented.
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TLDR
To consider an appropriate and safe initial dose for humans, necessary safety factors need to be applied to the animal data; these would include factors such as intra- and inter-species variability and for susceptible people in a population (such as drug users).
Safety of ibogaine administration in detoxification of opioid dependent individuals: a descriptive open-label observational study.
TLDR
An open-label observation study found that ibogaine treatment of patients with opioid use disorder can induce a clinically relevant but reversible QTc prolongation, bradycardia, and severe ataxia.
Treating drug dependence with the aid of ibogaine: A retrospective study
TLDR
A retrospective analysis of data from 75 previous alcohol, cannabis, cocaine and crack users suggests that ibogaine can be a safe and effective treatment for dependence on stimulant and other non-opiate drugs.
Mania following use of ibogaine: A case series.
TLDR
Clinicians are advised to be prepared for discussing the safety, efficacy, and paucity of good data regarding ibogaine with patients who may be considering its use, and to benefit from careful substance use and treatment history, specifically regarding opiates.
The adverse events of ibogaine in humans: an updated systematic review of the literature (2015-2020).
TLDR
There is a high need of phase I clinical trials that can describe the safety of different dosages of ibogaine with standardized products, and clinical profiling of vulnerable populations is performed.
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