Fatal toxicity associated with antidepressant use in primary care.

  title={Fatal toxicity associated with antidepressant use in primary care.},
  author={J M Mason and Nick Freemantle and Martin Paul Eccles},
  journal={The British journal of general practice : the journal of the Royal College of General Practitioners},
  volume={50 454},
BACKGROUND New selective serotonin reuptake inhibitors (SSRIs) are perceived to be much safer in use than older tricyclic antidepressants (TCAs). However, previous assessments of association with fatal toxicity were made too soon after the introduction of the new drugs to permit accurate estimation. AIM To determine the level of association of antidepressant drugs with fatal poisoning in the treatment of depression. METHOD National data for England and Wales for three years (1993 to 1995… CONTINUE READING


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