Cerebrovascular reactivity measured by functional magnetic resonance imaging during breath-hold challenge: A systematic review.
ACETAZOLAMIDE is known to produce many minor side-effects when given for any length of time. Becker and Middleton (1955) have described the following in seventy patients receiving long-term acetazolamide for glaucoma: paresthesiae 61 per cent., gastrointestinal disturbances 49 per cent., excessive fatigue 16 per cent., urinary disturbances 4 per cent., hearing loss 3 per cent., leucopenia 3 per cent. The experience of Leopold, Eisenberg, and Yasuna (1955) was similar. Renal colic, stones, and crystallized acetazolamide in the renal tubules have been reported in 44 cases (Glushien and Fisher, 1956; Persky, Chambers, and Potts, 1956; Abeshouse and Applefeld, 1956; Gordon and Sheps, 1957; Barraquer and Escribano, 1957; Yates-Bell, 1958; Davies, 1959; Mackenzie, 1960). Skin rash (Spring, 1956) and serum sickness-like hypersensitivity (Moseley and Baroody, 1955) were found in three cases. More serious reactions include agranulocytosis (Pearson, Binder, and Neber, 1955), fatal bone-marrow depression (Underwood, 1956), and two cases (one fatal) of thrombocytopenia (Reisner and Morgan, 1956; Bertino, Rodman, and Myerson, 1957). This paper describes a third patient with a fatal reaction attributable to acetazolamide.