Topics from this paper
QTc Interval Prolongation Associated with Citalopram Overdose: A Case Report and Literature Review
- Psychology, Medicine
- Clinical neuropharmacology
The case of a healthy 21-year-old woman who developed QTc interval prolongation after ingestion of approximately 400 mg citalopram is reported, and the cardiac effects of cITALopram are discussed. Expand
The Authors’ Reply
The authors’ reply: Nothing is certain in medicine and, while there is a remote possibility that citalopram could have contributed to the deaths, some clinicians might decide to err on the side of safety and not choose citalipram as first-line treatment given the availability of suitable alternative drugs. Expand
Drug monitoring of a case of citalopram overdosage
- Drug and chemical toxicology
The case of a 54-year-old patient who developed QTc interval prolongation, followed by ventricular fibrillation episodes, 10 hours after admission to the ICU, in the setting of a citalopram overdose is reported. Expand
Revisited: Therapeutic and toxic blood concentrations of more than 1100 drugs and other xenobiotics
- Critical Care
The data provided are useful for the therapeutic monitoring of pharmacotherapies, to facilitate the diagnostic assessment and monitoring of acute and chronic intoxications as well as to support forensic and clinical expert opinions. Expand
Guidelines for reporting case studies and series on drug-induced QT interval prolongation and its complications following acute overdose
- Clinical toxicology
A QT reporting checklist is reported to ensure published case reports and series describing drug-induced QT interval prolongation in poisoning can contribute to the fund of knowledge of QT intervals prolongation, TdP and other malignant dysrhythmias. Expand
Postmortem analysis of human bone marrow aspirate - Quantitative determination of SSRI and SNRI drugs.
- Medicine, Chemistry
For the first time the MAE/UHPLC-TOFMS method was developed and used in order to determine the antidepressant drugs within the human bone marrow aspirate in real forensic cases and allows for quantification of all mentioned drugs at therapeutic levels. Expand
Distribution of Eight QT-Prolonging Drugs and Their Main Metabolites Between Postmortem Cardiac Tissue and Blood Reveals Potential Pitfalls in Toxicological Interpretation.
- Journal of analytical toxicology
Cardiac tissue and femoral and cardiac blood concentrations were examined for eight frequently used QT-prolonging drugs (QTD) and their metabolites in a mentally ill population and citalopram displayed a wide overlap in cardiac tissue concentrations between non-toxic and toxic cITALopram cases, as estimated from femoral blood concentrations. Expand
The role of chronic nutritional supplements consumption in a fulminant serotonin syndrome due to citalopram intoxication.
- Medicina intensiva
The case of a previously healthy 42-yearold man with a history of chronic tobacco and alcohol consumption who was recently diagnosed for depression, who took a moderated overdose of citalopram and alcohol and died after 72 h, is reported. Expand
Selective serotonin reuptake inhibitors and cardiovascular events: A systematic review
- Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences
Both beneficial and adverse cardiovascular events can be established following the chronic use of various types of SSRIs, and the cardiovascular effect of each SSRI has to be carefully considered, based on patients' cardiovascular risk profiles. Expand
Citalopram Overdose: a Fatal Case
- Journal of Medical Toxicology
The clinician must be aware of the potential for large ingestions of citalopram to produce life-threatening effects and monitor closely for the neurologic, cardiovascular, and other manifestations that, in rare cases, can be fatal. Expand
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Five fatal cases of serotonin syndrome after moclobemide-citalopram or moclobemide-clomipramine overdoses
- The Lancet
Blood and tissue concentrations of tricyclic antidepressant drugs in post mortem cases: literature survey and a study of forty deaths.
- Journal of analytical toxicology
Comparing TCA drug concentrations in the heart and skeletal muscle and considering the differences in perfusion to these organs, TCA drugs and metabolites showed an affinity for the cardiac over the skeletal muscle. Expand
Studies on acute toxicity and drug levels of citalopram in the dog.
- Acta pharmacologica et toxicologica
Since no electrocardiographic changes were seen in conscious dogs even during pauses in the convulsive seizure it is concluded that citalopram does not exert cardiotoxic effects in the dog. Expand