Fatal necrotizing encephalopathy complicating treatment of malignant gliomas with intra-arterial BCNU and irradiation: A pathological study

@article{Rosenblum1989FatalNE,
  title={Fatal necrotizing encephalopathy complicating treatment of malignant gliomas with intra-arterial BCNU and irradiation: A pathological study},
  author={Marc K. Rosenblum and Jean-Yves Delattre and Russell W. Walker and William R. Shapiro},
  journal={Journal of Neuro-Oncology},
  year={1989},
  volume={7},
  pages={269-281}
}
We describe the neuropathologic findings at autopsy in six patients who developed a progressive encephalopathy complicating the treatment of malignant gliomas with combined intra-arterial 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) and cerebral irradiation. Four brains were free of tumor and one contained a microscopic focus of residual glioma. In only one case was there evidence of tumor progression. A disseminated process characterized by miliary foci of necrosis with mineralizing axonopathy… CONTINUE READING

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1 Excerpt

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