Fatal myocardial rupture after acute myocardial infarction complicated by heart failure, left ventricular dysfunction, or both: the VALsartan In Acute myocardial iNfarcTion Trial (VALIANT).

@article{Shamshad2010FatalMR,
  title={Fatal myocardial rupture after acute myocardial infarction complicated by heart failure, left ventricular dysfunction, or both: the VALsartan In Acute myocardial iNfarcTion Trial (VALIANT).},
  author={Faisal Shamshad and Satish Kenchaiah and Peter V. Finn and Jordi Soler-Soler and John J V McMurray and Eric Jose Velazquez and Aldo Pietro Maggioni and Robert M. Califf and Karl Swedberg and Lars Kober and Yuri N Belenkov and Sergei Varshavsky and Marc Pfeffer and Scott Solomon},
  journal={American heart journal},
  year={2010},
  volume={160 1},
  pages={145-51}
}
BACKGROUND Myocardial rupture is a relatively rare and usually fatal complication of myocardial infarction (MI). Early recognition of patients at greatest risk of myocardial rupture provides an opportunity for early intervention. METHODS VALIANT was a double-blind, randomized, controlled trial comparing valsartan, captopril, and their combination in high-risk patients post-MI. Myocardial rupture was identified by autopsy (available in 138/589 patients dying within 30 days of index MI… CONTINUE READING

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