Fatal liver failure in an adult patient with acute lymphoblastic leukemia following treatment with L-asparaginase.

@article{Bodmer2006FatalLF,
  title={Fatal liver failure in an adult patient with acute lymphoblastic leukemia following treatment with L-asparaginase.},
  author={Michael Bodmer and Michael Christian Sulz and Sylvia Stadlmann and Armin Droll and Luigi Maria Terracciano and Stephan Kr{\"a}henb{\"u}hl},
  journal={Digestion},
  year={2006},
  volume={74 1},
  pages={28-32}
}
L-Asparaginase is commonly used in combination chemotherapy of both pediatric and adult acute lymphoblastic leukemia. The majority of adverse effects are hypersensitivity reactions, but serious liver injury may also occur. It has been shown that treatment with L-asparaginase can be associated mainly with macrovesicular hepatic steatosis which may be accompanied by alterations in lipid metabolism. So far, the mechanism for liver injury associated with L-asparaginase is not known. We report here… CONTINUE READING

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