Fatal intoxication cases: cytochrome P 450 2D6 and 2C19 genotype distributions

  title={Fatal intoxication cases: cytochrome P 450 2D6 and 2C19 genotype distributions},
  author={A. Zackrisson and P. Holmgren and A. Gladh and J. Ahlner and B. Lindblom},
  journal={European Journal of Clinical Pharmacology},
Objective Many commonly used pharmaceuticals, such as antidepressants and neuroleptics as well as some illegal drugs, are metabolised by the cytochrome P 450 enzyme debrisoquine 4-hydroxylase (CYP2D6). Of Caucasians, 7–10% lack this enzyme, which can, upon administration of drugs in normal therapeutic doses, lead to adverse reactions and unexpected intoxication, leading in turn even to a fatal outcome in some cases.MethodsIndividuals (n=242) who had died due to intoxication by pharmaceuticals… Expand
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