Fatal hepatic vascular toxicity of DTIC. Is it really a rare event?

@article{Ceci1988FatalHV,
  title={Fatal hepatic vascular toxicity of DTIC. Is it really a rare event?},
  author={Guido Ceci and Mariangela Bella and Massimo Melissari and Marzio Gabrielli and P Bocchi and Giorgio Cocconi},
  journal={Cancer},
  year={1988},
  volume={61 10},
  pages={1988-91}
}
A fatal massive hepatic necrosis with widespread thrombotic occlusion of the small hepatic veins developed in two of 68 patients treated with DTIC for advanced melanoma in a randomized study. Thirteen similar reactions, in patients treated with single-agent DTIC, are reported in the literature. Several clinical and pathologic features distinguish this DTIC toxicity from Budd-Chiari syndrome and veno-occlusive disease (both well-known types of possibly drug-related hepatic vascular disease) and… CONTINUE READING