Fatal hemorrhage induced by subtilase cytotoxin from Shiga-toxigenic Escherichia coli.

  title={Fatal hemorrhage induced by subtilase cytotoxin from Shiga-toxigenic Escherichia coli.},
  author={Takeshi Furukawa and Kinnosuke Yahiro and Atsushi B Tsuji and Yasuhiro Terasaki and Naoko Morinaga and Masaru Miyazaki and Yuh Fukuda and Tsuneo Saga and Joel Moss and M. T. Noda},
  journal={Microbial pathogenesis},
  volume={50 3-4},
Subtilase cytotoxin (SubAB) is an AB(5) type toxin produced by a subset of Shiga-toxigenic Escherichia coli. The A subunit is a subtilase-like serine protease and cleaves an endoplasmic reticulum chaperone BiP. The B subunit binds to a receptor on the cell surface. Although SubAB is lethal for mice, the cause of death is not clear. In this study, we demonstrate in mice that SubAB induced small bowel hemorrhage and a coagulopathy characterized by thrombocytopenia, prolonged prothrombin time and… CONTINUE READING


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