Fatal connections: when DNA ends meet on the nuclear matrix.

  title={Fatal connections: when DNA ends meet on the nuclear matrix.},
  author={J{\"u}rgen Bode and Craig J. Benham and Erik Ernst and A. Knopp and Rolf Marschalek and Reiner Strick and Pamela L. Strissel},
  journal={Journal of cellular biochemistry. Supplement},
  volume={Suppl 35},
A damaged nucleus has long been regarded simply as a "bag of broken chromosomes," with the DNA free ends moving around and forming connections with randomly encountered partners. Recent evidence shows this picture to be fundamentally wrong. Chromosomes occupy specific nuclear domains within which only limited movement is possible. In a human diploid nucleus, 6.6 x 10(9) base pairs (bp) of DNA are compartmentalized into chromosomes in a way that allows stringent control of replication… CONTINUE READING