Fatal avian influenza A (H5N1) in a child presenting with diarrhea followed by coma.

@article{deJong2005FatalAI,
  title={Fatal avian influenza A (H5N1) in a child presenting with diarrhea followed by coma.},
  author={Menno D. de Jong and Van Cam Bach and Tu Qui Phan and Minh Hien Vo and Tan Thanh Tran and Bach Hue Nguyen and Marcel Ghm Beld and Thi Phuong Thao Le and Huu Khanh Truong and Van Vinh Chau Nguyen and Tinh Hien Tran and Quang Ha Do and Jeremy J. Farrar},
  journal={The New England journal of medicine},
  year={2005},
  volume={352 7},
  pages={
          686-91
        }
}
In southern Vietnam, a four-year-old boy presented with severe diarrhea, followed by seizures, coma, and death. The cerebrospinal fluid contained 1 white cell per cubic millimeter, normal glucose levels, and increased levels of protein (0.81 g per liter). The diagnosis of avian influenza A (H5N1) was established by isolation of the virus from cerebrospinal fluid, fecal, throat, and serum specimens. The patient's nine-year-old sister had died from a similar syndrome two weeks earlier. In both… 

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References

SHOWING 1-10 OF 26 REFERENCES

Avian influenza A (H5N1) in 10 patients in Vietnam.

Although in all 10 cases the infection appears to have been acquired directly from infected poultry, the potential exists for genetic reassortment with human influenzaviruses and the evolution of human-to-human transmission.

Encephalitis and encephalopathy associated with an influenza epidemic in Japan.

  • T. MorishimaT. Togashi N. Okabe
  • Medicine, Psychology
    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
  • 2002
F influenza-associated encephalitis/encephalopathy progressed rapidly and was associated with poor outcomes, and thrombocytopenia and severely elevated transaminase levels were factors associated with a poor prognosis.

Neurotropism of the 1997 Hong Kong H5N1 influenza virus in mice.

Acute Encephalopathy Associated with Influenza A Virus Infection

Influenza A virus–associated acute encephalopathy is frequently associated with metabolic disorders, whereas postinfluenzal encephalopathic appears to have different possible etiologies.

Distinct Pathogenesis of Hong Kong-Origin H5N1 Viruses in Mice Compared to That of Other Highly Pathogenic H5 Avian Influenza Viruses

Four additional highly pathogenic H5 avian influenza viruses were analyzed for pathogenicity in 6- to 8-week-old BALB/c mice and caused severe disease in mice, characterized by induced hypothermia, clinical signs, rapid weight loss, and 75 to 100% mortality by 6 to 8 days postinfection.

Biological Heterogeneity, Including Systemic Replication in Mice, of H5N1 Influenza A Virus Isolates from Humans in Hong Kong

The ability of these H5N1 viruses to produce systemic infection in mice and the clear differences in pathogenicity among the isolates studied here indicate that this system provides a useful model for studying the pathogenesis of avian influenza virus infection in mammals.

H5N1 influenza: a protean pandemic threat.

  • Y. GuanL. Poon J. Peiris
  • Biology, Medicine
    Proceedings of the National Academy of Sciences of the United States of America
  • 2004
The acquisition by the viruses of characteristics that enhance virulence in humans and waterfowl and their potential for wider distribution by infected migrating birds are causes for renewed pandemic concern.

Proved viraemia in asian influenza (Hong Kong variant) during incubation period

During an outbreak of influenza specimens were obtained from 21 patients with influenza-like illnesses and from 29 healthy subjects in close contact with the patients. Throat washings from 12 of the

A Mouse Model for the Evaluation of Pathogenesis and Immunity to Influenza A (H5N1) Viruses Isolated from Humans

This is the first demonstration of an influenza A virus that replicates systemically in a mammalian species and is neurotropic without prior adaptation and suggests a strategy of vaccine preparedness for rapid intervention in future influenza pandemics that uses antigenically related nonpathogenic viruses as vaccine candidates.