Fatal and nonfatal hepatotoxicity associated with flutamide.

  title={Fatal and nonfatal hepatotoxicity associated with flutamide.},
  author={Diane K. Wysowski and J P Freiman and John B. Tourtelot and Matthew D. Horton},
  journal={Annals of internal medicine},
  volume={118 11},
OBJECTIVE To identify and describe patients with hepatotoxicity possibly caused by flutamide, an antiandrogen drug. DESIGN Case series of reports, submitted to the Adverse Drug Event Reporting System of the Food and Drug Administration. SETTING Outpatient clinics and physicians' offices in the United States. PATIENTS Nineteen patients treated with flutamide for prostate cancer or benign prostatic hypertrophy (for Investigation of a New Drug or off-label use). MEASUREMENTS Evidence of… CONTINUE READING
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