Fatal Hydrocodone Overdose in a Child: Pharmacogenetics and Drug Interactions

@article{Madadi2010FatalHO,
  title={Fatal Hydrocodone Overdose in a Child: Pharmacogenetics and Drug Interactions},
  author={Parvaz Madadi and Doris Hildebrandt and Inna Y. Gong and Ute I. Schwarz and Catherine Ciszkowski and Colin J D Ross and Johanna Sistonen and Bruce C. Carleton and Michael R. Hayden and Albert Edward Lauwers and Gideon Koren},
  journal={Pediatrics},
  year={2010},
  volume={126},
  pages={e986 - e989}
}
Fatal opioid toxicity occurred in a developmentally delayed child aged 5 years 9 months who was inadvertently administered high doses of hydrocodone for a respiratory tract infection. [] Key Result The concentration of hydrocodone in postmortem blood was in the range associated with fatality; however, hydromorphone, a major metabolite catalyzed by cytochrome P450 2D6 (CYP2D6), was not detected when using mass spectrometry.

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