Fatal Hydrocodone Overdose in a Child: Pharmacogenetics and Drug Interactions

  title={Fatal Hydrocodone Overdose in a Child: Pharmacogenetics and Drug Interactions},
  author={P. Madadi and D. Hildebrandt and I. Y. Gong and U. I. Schwarz and C. Ciszkowski and C. J. D. Ross and J. Sistonen and B. Carleton and M. R. Hayden and A. E. Lauwers and G. Koren},
  pages={e986 - e989}
  • P. Madadi, D. Hildebrandt, +8 authors G. Koren
  • Published 2010
  • Medicine
  • Pediatrics
  • Fatal opioid toxicity occurred in a developmentally delayed child aged 5 years 9 months who was inadvertently administered high doses of hydrocodone for a respiratory tract infection. [...] Key Result The concentration of hydrocodone in postmortem blood was in the range associated with fatality; however, hydromorphone, a major metabolite catalyzed by cytochrome P450 2D6 (CYP2D6), was not detected when using mass spectrometry.Expand Abstract
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